Compressive mapping for next-generation sequencing
نویسندگان
چکیده
منابع مشابه
Mapping translocation breakpoints by next-generation sequencing.
Balanced chromosome rearrangements (BCRs) can cause genetic diseases by disrupting or inactivating specific genes, and the characterization of breakpoints in disease-associated BCRs has been instrumental in the molecular elucidation of a wide variety of genetic disorders. However, mapping chromosome breakpoints using traditional methods, such as in situ hybridization with fluorescent dye-labele...
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1 The Ohio State University, Dept. of Biomedical Informatics, {bozdagd,umit}@bmi.osu.edu 2 Applied Biosystems, [email protected] With the advent of next-generation high throughput sequencing instruments, large volumes of short sequence data are generated at an unprecedented rate. Processing and analyzing these massive data requires overcoming several challenges. A particular challen...
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ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 2016
ISSN: 1087-0156,1546-1696
DOI: 10.1038/nbt.3511